IUI (Intrauterine insemination)

Intrauterine insemination (IUI) is a fertility procedure in which sperm are washed, concentrated, and injected directly into a woman's uterus. The most common indications for IUI are cervical mucus abnormalities, low sperm count, low sperm motility, increased sperm viscosity or antisperm antibodies, unexplained infertility, and the need to use frozen donor sperm. In natural intercourse, only a fraction of the sperm make it past the woman's cervical mucus into the uterus. IUI increases the number of sperm in the fallopian tubes, where fertilization takes place.


Studies show that IUI is most successful when it is coupled with fertility drugs that recruit multiple follicles. This technique often is called controlled ovarian stimulation and IUI.


IUI sometimes is recommended for couples with unspecified infertility who have been trying to have a baby for six to 12 months. You should have a thorough infertility evaluation before trying IUI.


Male Partner Requirements for IUI


IUI relies on the natural ability of sperm to fertilize an egg in the fallopian tubes. Studies show that IUI will not be effective in cases where the male has low sperm counts or poor sperm shape (also known as sperm morphology). Sperm tests are required, therefore, in order to indicate:

  • Sperm count (number of sperm per cc)
  • Sperm motility (percentage of sperm moving)
  • Sperm morphology (shape)

In addition, California state law requires that the male (or female) partner must have blood work done to rule out certain infectious diseases.


Female Patient Requirements for IUI


The patient should have normal day 3 blood test results, open fallopian tubes, and a normal uterine cavity.

    Women with ovulatory disorders can be candidates for IUI if they respond adequately to fertility drugs. In these cases, hormone treatments stimulate follicle growth and the IUI is timed to take place after ovulation is induced. Hormone treatments are usually used even for women without ovulatory disorder.

    Women with mild endometriosis may benefit from IUI if they do not have a distortion of the pelvic structures.

    Women with severely damaged or blocked fallopian tubes are not candidates for IUI.




Follicular monitoring is done in the patient scheduled for IUI (either stimulated or un stimulated cycle),. When the developing follicle reach a particular size ovulation is triggered with the help of injection. After the injection the follicle ruptures (ovulation) within 36 hrs. IUI is planned accordingly.


The husband's semen is collected and processed to remove the unwanted cells and abnormal sperms so as to separate the most normal and the most motile sperms. This takes approximately 1-1 ½ hrs. The semen concentrate is inseminated with the help of a special catheter inside the uterus. The procedure is simple though the success rate is not very high(15 -20 % per cycle). This IUI may have to be repeated 4-5 times.


Donor Insemination


Donor semen is used for IUI in patients with azoospermia or with poor quality of semen parameters such as (severe Oligoasthenoteratozoospermia) where patients either cannot afford ICSI or have had repeated failures.


The donors of semen at Patankar Fertility Solutions are the voluntary donors from a good economical and academic background. They are thoroughly investigated before accepting them as the donors in the ART programme. The investigations are repeated every 6 months to check the development of any infection or disease. We use only the frozen semen samples. The matching is done on the basis of the physical characteristics of the husband, his blood group, etc., as far as possible.